About us
Compound Center
Compound Center is a facility that provides support to Chemical Biology Consortium Sweden (CBCS) and Drug Discovery and Development hosted by SciLifeLab, a Swedish national center for molecular biosciences focusing on health and environmental research.
Through the SciLifeLab Compound Collection, academic research groups have access to approximately 350,000 small molecules for biological screening purposes. The collection is based on donations of high‑quality sets from the pharmaceutical industry (Biovitrum, Karobio, Orexo/Biolipox, KDev) and has been expanded with additional compounds from various commercial vendors.
The compounds are organized into representative screening sets, ranging from chemically diverse sets to approved drugs and pharmacological tool compounds. Focused sets are also available, such as kinase-, GPCR-, and PPI-targeted compounds. The SLL primary screening set is designed for a variety of bioassays—from isolated targets to phenotypic cell‑based assays and whole‑organism systems such as parasites, zebrafish, and plants.
The compounds possess lead‑ to drug‑like properties, with respect to parameters such as molecular weight, hydrogen bond acceptors/donors, lipophilicity, and polar surface area. Filters addressing reactivity, PAINs, and aggregation issues have been applied to ensure tractable hit compounds. After hit identification, follow‑up material is available for validation and downstream profiling.
Compound Center Storage & Automation
Compound Center and its STT3K‑Kiwi store offer fully automated storage and retrieval of compounds organized in 96‑tube racks. The STT3K‑Kiwi store has a capacity of 224,000 tubes, each containing a compound in 10 mM DMSO stored at –20 °C under humidity control.
The facility manages the national acoustic dispensing center equipped with:
- Agilent Bravo pipetting system
- Labcyte Echo 650 (integrated with access station)
- Labcyte Echo 550 (stand-alone instrument)
- Labcyte Echo 525 (stand-alone instrument)
Open access is offered to research groups after proper training.